Neglected Diseases

CGH is screening our diverse chemical library against the pathogens for neglected diseases of the developing world, including:

  • Viral Hemorrhagic Fevers are caused by multiple families of viruses, many of which cause severe, life-threatening disease. The majority of these viruses pose a serious risk as biological weapons and have been classified as Category A agents by the Centers for Disease Control and Prevention.
  • Leishmaniasis occurs in 98 countries with 350 million people living at risk of infection worldwide. This complex and diverse disease causes severe disfigurement, disability and death and is usually found in poor populations living in remote areas.
  • Chagas disease results in significant disability with great social and economic impact and is endemic in 21 countries across Latin America. This parasitic disease causes chronic pain, organ failure and death, and has been growing in non-endemic, developed countries.
  • Malaria, the leading parasitic cause of morbidity and mortality worldwide, is present in over 100 countries and threatens half of the world’s population. In Sub-Saharan Africa, it is the single largest cause of death for children under the age of 5 and costs an estimated $12 billion every year.
  • Lymphatic Filariasis is a parasitic infection that leads to the disease commonly known as elephantiasis that can result in an altered lymphatic system and abnormal enlargement of body parts. Filarial diseases are the most devastating of the NTDs in terms of social and economic impact; the disease causes disability and disfiguring effects for infected individuals and leads to social stigmatization and isolation.
  • Tuberculosis (TB) is a pandemic bacterial disease commonly affecting lungs with the vast majority of cases occurring in low- and middle-income countries. TB is the leading cause of death of people living with HIV, and multi-drug resistant TB is present in virtually all countries.
  • Human and Animal African Trypanosomiasis (HAT and AAT) occurs in humans (sleeping sickness) and feed/work animals in 37 African countries. Approximately 60 million people are at risk of being infected with HAT, which can cause severe neurological conditions and death. The cattle disease manifests as wasting and has a severe economic impact ($1-1.2 billion /year), worsening the social and living standard of the poorest people in Sub-Saharan Africa. Current treatments for both the human and animal disease entail the use of prohibitive delivery methods.